Assay Detail
Binding
CHEMBL680029
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Tested for inhibition of Epidermal growth factor receptor from A431 vulval squamous carcinoma cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | A-431 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Epidermal growth factor receptor tyrosine kinase: Structure-activity relationships and antitumour activity of novel quinazolines
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.77 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329867 | — | — | 1 | 8.19 |
| CHEMBL301018 | — | — | 1 | 8.05 |
| CHEMBL419137 | — | — | 1 | 8.00 |
| CHEMBL91484 | — | — | 1 | 7.57 |
| CHEMBL90540 | — | — | 1 | 7.08 |
| CHEMBL93173 | — | — | 1 | 6.77 |
| CHEMBL330323 | — | — | 1 | 6.70 |
| CHEMBL420059 | — | — | 1 | 6.52 |
| CHEMBL93423 | — | — | 1 | 6.41 |
| CHEMBL422066 | — | — | 1 | 6.37 |
| CHEMBL91428 | — | — | 1 | 6.18 |
| CHEMBL92006 | — | — | 1 | 6.14 |
| CHEMBL330668 | — | — | 1 | 6.11 |
| CHEMBL90541 | — | — | 1 | 6.09 |
| CHEMBL328277 | — | — | 1 | 6.09 |
| CHEMBL94019 | — | — | 1 | 6.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329867 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL301018 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL419137 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL91484 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL90540 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL93173 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL330323 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL420059 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93423 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL422066 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL91428 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL92006 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL330668 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL90541 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL328277 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL94019 | — | IC50 | = | 910.0 | nM | 6.04 |