Assay Detail
Binding
CHEMBL680072
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Binding affinity against Diazepam sensitive (DS) Gamma-aminobutyric acid A receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Synthesis of novel imidazobenzodiazepines as probes of the pharmacophore for "diazepam-insensitive" GABAA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.68 | 8.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL46482 | — | — | 1 | 8.61 |
| CHEMBL416450 | — | — | 1 | 8.15 |
| CHEMBL45346 | — | — | 1 | 6.29 |
| CHEMBL43718 | — | — | 1 | - |
| CHEMBL295277 | — | — | 1 | - |
| CHEMBL44784 | — | — | 1 | - |
| CHEMBL43725 | — | — | 1 | - |
| CHEMBL45174 | — | — | 1 | - |
| CHEMBL46957 | — | — | 1 | - |
| CHEMBL43724 | — | — | 1 | - |
| CHEMBL295981 | — | — | 1 | - |
| CHEMBL47853 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL46482 | — | IC50 | = | 2.47 | nM | 8.61 |
| CHEMBL416450 | — | IC50 | = | 7.07 | nM | 8.15 |
| CHEMBL45346 | — | IC50 | = | 514.0 | nM | 6.29 |
| CHEMBL43718 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL295277 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL44784 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL43725 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL45174 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL46957 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL43724 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL295981 | — | IC50 | > | 500.0 | nM | - |
| CHEMBL47853 | — | IC50 | > | 1000.0 | nM | - |