Assay Detail
Binding
CHEMBL680078
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In vitro inhibition of Farnesyltransferase
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.93 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301667 | — | — | 1 | 7.40 |
| CHEMBL417600 | — | — | 1 | 6.94 |
| CHEMBL70620 | — | — | 1 | 6.82 |
| CHEMBL55423 | — | — | 1 | 6.70 |
| CHEMBL292164 | — | — | 1 | 6.15 |
| CHEMBL53732 | — | — | 1 | 6.04 |
| CHEMBL55527 | — | — | 1 | 5.97 |
| CHEMBL72126 | — | — | 1 | 5.34 |
| CHEMBL71714 | — | — | 1 | 4.96 |
| CHEMBL71370 | — | — | 1 | 4.87 |
| CHEMBL69076 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301667 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL417600 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL70620 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL55423 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL292164 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL53732 | — | IC50 | = | 917.0 | nM | 6.04 |
| CHEMBL55527 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL72126 | — | IC50 | = | 4575.0 | nM | 5.34 |
| CHEMBL71714 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL71370 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL69076 | — | IC50 | = | 100000.0 | nM | 4.00 |