Compound Detail
CHEMBL292164
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Basic Information
| ChEMBL ID | CHEMBL292164 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NLKGJZMAJPDFMS-OAHLLOKOSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
272.4
MW (Da)
3.33
ALogP
3
HBA
3
HBD
38.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.15 | 6.13 | 710.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 710.0 | nM | 6.15 | In vitro inhibition of Farnesyltransferase | 8568811 |
| Protein farnesyltransferase | IC50 | = | 770.0 | nM | 6.11 | Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells | 11754590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8568811 | 10.1021/jm950414g | Protein farnesyltransferase | 1 |
| 8568811 | 10.1021/jm950414g | Geranylgeranyl transferase type I | 1 |
| 11754590 | 10.1021/jm0103099 | Protein farnesyltransferase | 1 |
| 11754590 | 10.1021/jm0103099 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine