Assay Detail
Binding
CHEMBL680080
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Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.57 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54044 | — | — | 1 | 9.21 |
| CHEMBL55497 | — | — | 1 | 7.70 |
| CHEMBL55639 | — | — | 1 | 7.52 |
| CHEMBL301667 | — | — | 1 | 7.43 |
| CHEMBL58822 | — | — | 1 | 7.39 |
| CHEMBL417600 | — | — | 1 | 6.82 |
| CHEMBL54279 | — | — | 1 | 6.82 |
| CHEMBL299245 | — | — | 1 | 6.51 |
| CHEMBL55423 | — | — | 1 | 6.47 |
| CHEMBL292361 | — | — | 1 | 6.42 |
| CHEMBL55427 | — | — | 1 | 6.37 |
| CHEMBL55484 | — | — | 1 | 6.35 |
| CHEMBL292164 | — | — | 1 | 6.11 |
| CHEMBL53732 | — | — | 1 | 6.03 |
| CHEMBL55527 | — | — | 1 | 5.92 |
| CHEMBL55893 | — | — | 1 | 5.64 |
| CHEMBL301433 | — | — | 1 | 5.54 |
| CHEMBL54366 | — | — | 1 | 5.42 |
| CHEMBL301842 | — | — | 1 | 5.25 |
| CHEMBL293110 | — | — | 1 | - |
| CHEMBL55306 | — | — | 1 | - |
| CHEMBL56949 | — | — | 1 | - |
| CHEMBL266005 | — | — | 1 | - |
| CHEMBL298613 | — | — | 1 | - |
| CHEMBL55676 | — | — | 1 | - |
| CHEMBL55514 | — | — | 1 | - |
| CHEMBL53999 | — | — | 1 | - |
| CHEMBL299489 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54044 | — | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL55497 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL55639 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL301667 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL58822 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL417600 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL54279 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL299245 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL55423 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL292361 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL55427 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL55484 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL292164 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL53732 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL55527 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL55893 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL301433 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL54366 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL301842 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL293110 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55306 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL56949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL266005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL298613 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL53999 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL299489 | — | IC50 | > | 10000.0 | nM | - |