Compound Detail
CHEMBL55639
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Basic Information
| ChEMBL ID | CHEMBL55639 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UOXSWKQZOSEOLM-CQSZACIVSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
326.4
MW (Da)
3.85
ALogP
7
HBA
3
HBD
87.5
PSA (Ų)
0.70
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 5.36 | 5.36 | 4400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 30.0 | nM | 7.52 | Inhibition of farnesyltransferase from human Burkitt lymphoma (Daudi) cells | 11754590 |
| Geranylgeranyl transferase type I | IC50 | = | 4400.0 | nM | 5.36 | Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) fr... | 11754590 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11754590 | 10.1021/jm0103099 | Protein farnesyltransferase | 1 |
| 11754590 | 10.1021/jm0103099 | Geranylgeranyl transferase type I | 1 |
Data from ChEMBL 36 via Core Engine