Assay Detail
Binding
CHEMBL686124
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Inhibition of partially purified Geranylgeranyl transferase type I (GGTase-I) from human Burkitt lymphoma (Daudi) cells
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Geranylgeranyl transferase type I (CHEMBL2095164) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.11 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55497 | — | — | 1 | 6.19 |
| CHEMBL58822 | — | — | 1 | 5.62 |
| CHEMBL55484 | — | — | 1 | 5.41 |
| CHEMBL55639 | — | — | 1 | 5.36 |
| CHEMBL55427 | — | — | 1 | 5.36 |
| CHEMBL55893 | — | — | 1 | 5.30 |
| CHEMBL299245 | — | — | 1 | 5.23 |
| CHEMBL301433 | — | — | 1 | 5.16 |
| CHEMBL292361 | — | — | 1 | 5.16 |
| CHEMBL301667 | — | — | 1 | 4.46 |
| CHEMBL417600 | — | — | 1 | 4.05 |
| CHEMBL53732 | — | — | 1 | 4.00 |
| CHEMBL55676 | — | — | 1 | - |
| CHEMBL299489 | — | — | 1 | - |
| CHEMBL292164 | — | — | 1 | - |
| CHEMBL301842 | — | — | 1 | - |
| CHEMBL55306 | — | — | 1 | - |
| CHEMBL54366 | — | — | 1 | - |
| CHEMBL56949 | — | — | 1 | - |
| CHEMBL266005 | — | — | 1 | - |
| CHEMBL293110 | — | — | 1 | - |
| CHEMBL53999 | — | — | 1 | - |
| CHEMBL55514 | — | — | 1 | - |
| CHEMBL55527 | — | — | 1 | - |
| CHEMBL298613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55497 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL58822 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL55484 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL55639 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL55427 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL55893 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL299245 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL301433 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL292361 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL301667 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL417600 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL53732 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55676 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL299489 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL292164 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL301842 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55306 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL54366 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL56949 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL266005 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL293110 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL53999 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55514 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL55527 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298613 | — | IC50 | > | 10000.0 | nM | - |