Assay Detail
Binding
CHEMBL680103
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on CHO cells in presence of Mg+2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent, orally absorbed glucagon receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.05 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351772 | — | — | 1 | 6.60 |
| CHEMBL156458 | — | — | 1 | 6.16 |
| CHEMBL160287 | — | — | 1 | 6.08 |
| CHEMBL155686 | — | — | 1 | 6.00 |
| CHEMBL158676 | — | — | 1 | 5.92 |
| CHEMBL158548 | — | — | 1 | 5.52 |
| CHEMBL160735 | — | — | 1 | - |
| CHEMBL160372 | — | — | 1 | - |
| CHEMBL348555 | — | — | 1 | - |
| CHEMBL345863 | — | — | 1 | - |
| CHEMBL347462 | — | — | 1 | - |
| CHEMBL348401 | — | — | 1 | - |
| CHEMBL160561 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351772 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL156458 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL160287 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL155686 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL158676 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL158548 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL160735 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL160372 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL348555 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL345863 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL347462 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL348401 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL160561 | — | IC50 | > | 1000.0 | nM | - |