Compound Detail
CHEMBL160287
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL160287 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XDRUMTNYWFDQKD-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
467.8
MW (Da)
7.62
ALogP
2
HBA
1
HBD
37.9
PSA (Ų)
0.32
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucagon receptor CHEMBL1985 | IC50 | 8.4 | 7.645 | 4.0 | 2 |
| Glucagon receptor CHEMBL4773 | IC50 | 7.31 | 6.695 | 49.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucagon receptor | IC50 | = | 4.0 | nM | 8.4 | Binding affinity determined by reduction in binding of 125 I-glucagon to the hum... | 10201821 |
| Glucagon receptor | IC50 | = | 49.0 | nM | 7.31 | Binding affinity towards glucagon receptor determined by reduction in binding of... | 10201821 |
| Glucagon receptor | IC50 | = | 130.0 | nM | 6.89 | Binding affinity towards glucagon receptor determined by reduction in binding of... | 10201821 |
| Glucagon receptor | IC50 | = | 830.0 | nM | 6.08 | Binding affinity towards glucagon receptor determined by reduction in binding of... | 10201821 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10201821 | 10.1016/s0960-894x(99)00081-5 | Glucagon receptor | 4 |
| 10201821 | 10.1016/s0960-894x(99)00081-5 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine