Assay Detail
Binding
CHEMBL680188
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Binding affinity against human glucocorticoid receptor expressed in SF-12 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | SF-12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.90 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 7.88 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL137103 | — | — | 1 | 6.76 |
| CHEMBL32812 | — | — | 1 | 6.75 |
| CHEMBL342426 | — | — | 1 | 6.62 |
| CHEMBL134421 | — | — | 1 | 6.52 |
| CHEMBL302362 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL103 | PROGESTERONE | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL137103 | — | Ki | = | 173.0 | nM | 6.76 |
| CHEMBL32812 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL342426 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL134421 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL302362 | — | Ki | = | 564.0 | nM | 6.25 |