Assay Detail
Binding
CHEMBL680189
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Binding affinity against baculovirus expressed human glucocorticoid receptor (hGR)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2,3,4-tetrahydrochromeno[3,4-f]quinolin-3-ones as a novel class of nonsteroidal progesterone receptor agonists: effect of A-ring modification.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.50 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 7.88 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL36564 | — | — | 1 | 6.71 |
| CHEMBL286158 | — | — | 1 | 6.60 |
| CHEMBL284475 | — | — | 1 | 6.60 |
| CHEMBL36065 | — | — | 1 | 6.59 |
| CHEMBL35429 | — | — | 1 | 6.48 |
| CHEMBL32603 | — | — | 1 | 6.17 |
| CHEMBL35525 | — | — | 1 | 6.06 |
| CHEMBL34015 | — | — | 1 | 6.04 |
| CHEMBL285705 | — | — | 1 | 6.04 |
| CHEMBL34824 | — | — | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL103 | PROGESTERONE | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL36564 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL286158 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL284475 | — | Ki | = | 249.0 | nM | 6.60 |
| CHEMBL36065 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL35429 | — | Ki | = | 331.0 | nM | 6.48 |
| CHEMBL32603 | — | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL35525 | — | Ki | = | 864.0 | nM | 6.06 |
| CHEMBL34015 | — | Ki | = | 913.0 | nM | 6.04 |
| CHEMBL285705 | — | Ki | = | 909.0 | nM | 6.04 |
| CHEMBL34824 | — | Ki | = | 4728.0 | nM | 5.33 |