Assay Detail
Binding
CHEMBL680190
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Binding affinity for glucocorticoid receptor
11
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of non-steroidal ligands for the glucocorticoid receptor: selective quinoline derivatives with prednisolone-equivalent functional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 7.79 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99046 | — | — | 3 | 8.68 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.62 |
| CHEMBL419158 | — | — | 2 | 8.48 |
| CHEMBL97206 | — | — | 1 | 8.40 |
| CHEMBL318409 | — | — | 1 | 8.03 |
| CHEMBL95644 | — | — | 1 | 7.96 |
| CHEMBL317983 | — | — | 1 | 7.75 |
| CHEMBL99128 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99046 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL131 | PREDNISOLONE | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL419158 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL97206 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL99046 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL318409 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL95644 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL317983 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL419158 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL99046 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL99128 | — | Ki | = | 1800.0 | nM | 5.75 |