Assay Detail
Binding
CHEMBL680192
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity was determined on Human glucocorticoid receptor (hAR) using progesterone as radioligand.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 7.23 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 7.88 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.52 |
| CHEMBL430855 | — | — | 1 | 7.47 |
| CHEMBL102754 | — | — | 1 | 7.41 |
| CHEMBL101907 | — | — | 1 | 7.38 |
| CHEMBL318513 | — | — | 1 | 7.36 |
| CHEMBL320690 | — | — | 1 | 7.24 |
| CHEMBL317921 | — | — | 1 | 7.23 |
| CHEMBL103092 | — | — | 1 | 7.22 |
| CHEMBL103232 | — | — | 1 | 7.17 |
| CHEMBL102403 | — | — | 1 | 7.10 |
| CHEMBL102541 | — | — | 1 | 7.00 |
| CHEMBL102720 | — | — | 1 | 6.83 |
| CHEMBL286595 | — | — | 1 | 6.82 |
| CHEMBL101914 | — | — | 1 | 6.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL103 | PROGESTERONE | Ki | = | 30.5 | nM | 7.52 |
| CHEMBL430855 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL102754 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL101907 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL318513 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL320690 | — | Ki | = | 58.0 | nM | 7.24 |
| CHEMBL317921 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL103092 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL103232 | — | Ki | = | 67.0 | nM | 7.17 |
| CHEMBL102403 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL102541 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL102720 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL286595 | — | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL101914 | — | Ki | = | 154.0 | nM | 6.81 |