Assay Detail
Binding
CHEMBL680229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]gamma-amino butyric acid from Gamma-aminobutyric acid (GABA-A) receptor of rat ganglion neurons
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
New anticonvulsants: Schiff bases of gamma-aminobutyric acid and gamma-aminobutyramide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.77 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | 8.40 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.60 |
| CHEMBL160058 | — | — | 1 | 6.23 |
| CHEMBL287631 | PROGABIDE | 2.0 | 1 | 4.85 |
| CHEMBL433 | VALPROATE SODIUM | 4.0 | 1 | - |
| CHEMBL16 | PHENYTOIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL160058 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL287631 | PROGABIDE | Ki | = | 14000.0 | nM | 4.85 |
| CHEMBL433 | VALPROATE SODIUM | Ki | > | 100000.0 | nM | - |
| CHEMBL16 | PHENYTOIN | Ki | > | 100000.0 | nM | - |