Assay Detail
Binding
CHEMBL680275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of rat Gonadotropin-releasing hormone receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.25 | 5.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23830 | — | — | 1 | 5.66 |
| CHEMBL3085404 | — | — | 1 | 5.66 |
| CHEMBL283381 | — | — | 1 | 5.50 |
| CHEMBL22314 | — | — | 1 | 5.31 |
| CHEMBL23969 | — | — | 1 | 5.19 |
| CHEMBL22653 | — | — | 1 | 5.12 |
| CHEMBL279885 | — | — | 1 | 5.12 |
| CHEMBL423291 | — | — | 1 | 5.10 |
| CHEMBL23729 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23830 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3085404 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL283381 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL22314 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL23969 | — | Ki | = | 6400.0 | nM | 5.19 |
| CHEMBL22653 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL279885 | — | Ki | = | 7600.0 | nM | 5.12 |
| CHEMBL423291 | — | Ki | = | 7900.0 | nM | 5.10 |
| CHEMBL23729 | — | Ki | = | 25000.0 | nM | 4.60 |