Assay Detail
Functional
CHEMBL680354
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In vitro inhibitory activity against electrically evoked contractions of guinea pig ileum (GPI)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.78 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | — | 1 | 8.92 |
| CHEMBL606603 | — | — | 1 | 8.20 |
| CHEMBL109390 | — | — | 1 | 7.39 |
| CHEMBL607479 | — | — | 1 | 7.14 |
| CHEMBL607403 | — | — | 1 | 6.97 |
| CHEMBL607401 | — | — | 1 | 5.81 |
| CHEMBL442577 | — | — | 1 | 5.76 |
| CHEMBL607480 | — | — | 1 | 5.50 |
| CHEMBL607402 | — | — | 1 | 5.32 |
| CHEMBL26861 | — | — | 1 | - |
| CHEMBL606602 | — | — | 1 | - |
| CHEMBL607481 | — | — | 1 | - |
| CHEMBL606601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278789 | DERMORPHIN | IC50 | = | 1.21 | nM | 8.92 |
| CHEMBL606603 | — | IC50 | = | 6.36 | nM | 8.20 |
| CHEMBL109390 | — | IC50 | = | 40.7 | nM | 7.39 |
| CHEMBL607479 | — | IC50 | = | 71.7 | nM | 7.14 |
| CHEMBL607403 | — | IC50 | = | 107.5 | nM | 6.97 |
| CHEMBL607401 | — | IC50 | = | 1558.0 | nM | 5.81 |
| CHEMBL442577 | — | IC50 | = | 1724.0 | nM | 5.76 |
| CHEMBL607480 | — | IC50 | = | 3193.0 | nM | 5.50 |
| CHEMBL607402 | — | IC50 | = | 4740.0 | nM | 5.32 |
| CHEMBL26861 | — | IC50 | > | 1200.0 | nM | - |
| CHEMBL606602 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL607481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL606601 | — | IC50 | > | 10000.0 | nM | - |