Assay Detail
Binding
CHEMBL680403
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Binding affinity against gonadotropin-releasing hormone receptor of rat
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Initial structure-activity relationship studies of a novel series of pyrrolo[1,2-a]pyrimid-7-ones as GnRH receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.46 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339636 | — | — | 1 | 8.40 |
| CHEMBL71917 | — | — | 1 | 7.22 |
| CHEMBL11149 | — | — | 1 | 6.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339636 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL71917 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL11149 | — | IC50 | = | 170.0 | nM | 6.77 |