Assay Detail
Binding
CHEMBL680411
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Evaluated for gonadotropin-releasing hormone receptor binding by displacing the 50% of the bound tracer [125I][D-Lys6]-GnRH radioligand in rat pituitary receptors
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Gonadotropin-releasing hormone receptor (CHEMBL3066) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and evaluation of a long-acting, potent analogue of gonadotropin-releasing hormone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.92 | 10.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370519 | — | — | 1 | 10.10 |
| CHEMBL414239 | — | — | 1 | 10.05 |
| CHEMBL438099 | — | — | 1 | 9.60 |
| CHEMBL410632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370519 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL414239 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL438099 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL410632 | — | IC50 | = | 0.002 | nM | - |