Assay Detail
Functional
CHEMBL680424
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Effects of alkyl substitutions of xanthine skeleton on bronchodilation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 30 | 5.21 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446679 | — | — | 1 | 7.52 |
| CHEMBL157655 | — | — | 1 | 7.30 |
| CHEMBL278332 | — | — | 1 | 6.22 |
| CHEMBL28194 | — | — | 1 | 5.89 |
| CHEMBL130969 | — | — | 1 | 5.89 |
| CHEMBL132001 | — | — | 1 | 5.85 |
| CHEMBL286976 | — | — | 1 | 5.80 |
| CHEMBL131275 | — | — | 1 | 5.51 |
| CHEMBL334813 | — | — | 1 | 5.33 |
| CHEMBL282310 | — | — | 1 | 5.30 |
| CHEMBL283412 | — | — | 1 | 5.23 |
| CHEMBL279898 | ENPROFYLLINE | 2.0 | 1 | 5.14 |
| CHEMBL130503 | — | — | 1 | 5.12 |
| CHEMBL132052 | — | — | 1 | 5.12 |
| CHEMBL337001 | — | — | 1 | 5.08 |
| CHEMBL334849 | — | — | 1 | 5.08 |
| CHEMBL112369 | — | — | 1 | 5.02 |
| CHEMBL417654 | — | — | 1 | 4.97 |
| CHEMBL131164 | — | — | 1 | 4.86 |
| CHEMBL24107 | — | — | 1 | 4.82 |
| CHEMBL128900 | — | — | 1 | 4.81 |
| CHEMBL131371 | — | — | 1 | 4.56 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.55 |
| CHEMBL68278 | — | — | 1 | 4.36 |
| CHEMBL39986 | — | — | 1 | 4.21 |
| CHEMBL131181 | — | — | 1 | 4.16 |
| CHEMBL1250 | 1-METHYLXANTHINE | — | 1 | 4.12 |
| CHEMBL127167 | — | — | 1 | 4.02 |
| CHEMBL1424 | XANTHINE | — | 1 | - |
| CHEMBL619 | 3-METHYLXANTHINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446679 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL157655 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL278332 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL28194 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL130969 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL132001 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL286976 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL131275 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL334813 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL282310 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL283412 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL279898 | ENPROFYLLINE | EC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL130503 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL132052 | — | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL337001 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL334849 | — | EC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL112369 | — | EC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL417654 | — | EC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL131164 | — | EC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL24107 | — | EC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL128900 | — | EC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL131371 | — | EC50 | = | 27500.0 | nM | 4.56 |
| CHEMBL1355736 | THEOPHYLLINE | EC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL68278 | — | EC50 | = | 43400.0 | nM | 4.36 |
| CHEMBL39986 | — | EC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL131181 | — | EC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL1250 | 1-METHYLXANTHINE | EC50 | = | 75900.0 | nM | 4.12 |
| CHEMBL127167 | — | EC50 | = | 96200.0 | nM | 4.02 |
| CHEMBL1424 | XANTHINE | EC50 | > | 100000.0 | nM | - |
| CHEMBL619 | 3-METHYLXANTHINE | EC50 | > | 100000.0 | nM | - |