Assay Detail
Binding
CHEMBL680443
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Ro- 15-4513 from alpha-6 beta2 gamma2 subunits of Rat GABA-A receptor expressed in Sf-9 insect cell membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Target
GABA A receptor alpha-6/beta-2/gamma-2 (CHEMBL2111365) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
High-affinity alpha-aminobutyric acid A/benzodiazepine ligands: synthesis and structure-activity relationship studies of a new series of tetracyclic imidazoquinoxalines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.33 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142750 | — | — | 1 | 7.88 |
| CHEMBL15093 | PNU-91571 | — | 1 | 7.88 |
| CHEMBL279867 | PANADIPLON | 2.0 | 1 | 6.22 |
| CHEMBL343489 | — | — | 1 | - |
| CHEMBL143864 | — | — | 1 | - |
| CHEMBL343688 | — | — | 1 | - |
| CHEMBL264999 | — | — | 1 | - |
| CHEMBL141243 | — | — | 1 | - |
| CHEMBL140631 | — | — | 1 | - |
| CHEMBL142792 | — | — | 1 | - |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | - |
| CHEMBL357637 | — | — | 1 | - |
| CHEMBL142329 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142750 | — | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL15093 | PNU-91571 | Ki | = | 13.2 | nM | 7.88 |
| CHEMBL279867 | PANADIPLON | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL343489 | — | Ki | > | 589.0 | nM | - |
| CHEMBL143864 | — | Ki | > | 589.0 | nM | - |
| CHEMBL343688 | — | Ki | > | 589.0 | nM | - |
| CHEMBL264999 | — | Ki | > | 589.0 | nM | - |
| CHEMBL141243 | — | Ki | > | 589.0 | nM | - |
| CHEMBL140631 | — | Ki | > | 589.0 | nM | - |
| CHEMBL142792 | — | Ki | > | 589.0 | nM | - |
| CHEMBL12 | DIAZEPAM | Ki | > | 7000.0 | nM | - |
| CHEMBL357637 | — | Ki | > | 589.0 | nM | - |
| CHEMBL142329 | — | Ki | > | 589.0 | nM | - |