Compound Detail
CHEMBL142792
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL142792 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JPQHYVFTCPAEGO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
409.4
MW (Da)
4.18
ALogP
6
HBA
0
HBD
77.0
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.6
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GABA-A receptor; anion channel CHEMBL1907607 | Ki | 7.6 | 7.6 | 25.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GABA-A receptor; anion channel | Ki | = | 25.0 | nM | 7.6 | Displacement of [3H]flunitrazepam from GABA-A benzodiazepine receptor of rat cor... | 8917654 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8917654 | 10.1021/jm960401i | GABA-A receptor; anion channel | 2 |
| 8917654 | 10.1021/jm960401i | GABA A receptor alpha-6/beta-2/gamma-2 | 2 |
| 8917654 | 10.1021/jm960401i | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 8917654 | 10.1021/jm960401i | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine