Assay Detail
Functional
CHEMBL680489
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Relative change in CF was determined by calculating the effective concentration that produced a 50% of maximum increase in tension
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mustela putorius furo |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.14 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141000 | — | — | 1 | 6.77 |
| CHEMBL313458 | CARSATRIN | 2.0 | 1 | 6.52 |
| CHEMBL138026 | — | — | 1 | 6.41 |
| CHEMBL343546 | — | — | 1 | 6.36 |
| CHEMBL342703 | — | — | 1 | 6.33 |
| CHEMBL344707 | — | — | 1 | 6.30 |
| CHEMBL141693 | — | — | 1 | 6.30 |
| CHEMBL314639 | — | — | 1 | 6.30 |
| CHEMBL441094 | — | — | 1 | 6.22 |
| CHEMBL335793 | — | — | 1 | 6.16 |
| CHEMBL344372 | — | — | 1 | 6.00 |
| CHEMBL139373 | — | — | 1 | 5.96 |
| CHEMBL141949 | — | — | 1 | 5.80 |
| CHEMBL139038 | — | — | 1 | 5.72 |
| CHEMBL141619 | — | — | 1 | 5.68 |
| CHEMBL141814 | — | — | 1 | 5.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141000 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL313458 | CARSATRIN | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL138026 | — | EC50 | = | 390.0 | nM | 6.41 |
| CHEMBL343546 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL342703 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL344707 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL141693 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL314639 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL441094 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL335793 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL344372 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL139373 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL141949 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL139038 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL141619 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL141814 | — | EC50 | = | 3400.0 | nM | 5.47 |