Assay Detail
Binding
CHEMBL680528
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In vitro inhibitory activity against Farnesyltransferase (FTase)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Discovery of a series of cyclohexylethylamine-containing protein farnesyltransferase inhibitors exhibiting potent cellular activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 9.11 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL358363 | — | — | 1 | 9.85 |
| CHEMBL344771 | — | — | 1 | 9.80 |
| CHEMBL175628 | — | — | 1 | 9.77 |
| CHEMBL367324 | — | — | 1 | 9.77 |
| CHEMBL144175 | — | — | 1 | 9.70 |
| CHEMBL344100 | — | — | 1 | 9.70 |
| CHEMBL178483 | — | — | 1 | 9.66 |
| CHEMBL367008 | — | — | 1 | 9.60 |
| CHEMBL367456 | — | — | 1 | 9.55 |
| CHEMBL145317 | — | — | 1 | 9.39 |
| CHEMBL342315 | — | — | 1 | 9.38 |
| CHEMBL177452 | — | — | 1 | 9.34 |
| CHEMBL144536 | — | — | 1 | 9.22 |
| CHEMBL368038 | — | — | 1 | 9.18 |
| CHEMBL175682 | — | — | 1 | 9.15 |
| CHEMBL369548 | — | — | 1 | 9.15 |
| CHEMBL362186 | — | — | 1 | 9.06 |
| CHEMBL144745 | — | — | 1 | 9.00 |
| CHEMBL177340 | — | — | 1 | 8.96 |
| CHEMBL145699 | — | — | 1 | 8.92 |
| CHEMBL177445 | — | — | 1 | 8.54 |
| CHEMBL178430 | — | — | 1 | 8.46 |
| CHEMBL424119 | — | — | 1 | 8.40 |
| CHEMBL343435 | — | — | 1 | 8.34 |
| CHEMBL145417 | — | — | 1 | 8.10 |
| CHEMBL144183 | — | — | 1 | 8.00 |
| CHEMBL145950 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL358363 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL344771 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL175628 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL367324 | — | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL144175 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL344100 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL178483 | — | IC50 | = | 0.22 | nM | 9.66 |
| CHEMBL367008 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL367456 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL145317 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL342315 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL177452 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL144536 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL368038 | — | IC50 | = | 0.66 | nM | 9.18 |
| CHEMBL175682 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL369548 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL362186 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL144745 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL177340 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL145699 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL177445 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL178430 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL424119 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL343435 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL145417 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL144183 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL145950 | — | IC50 | = | 12.0 | nM | 7.92 |