Protein farnesyltransferase · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q04631. Use UniProt Q04631 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q04631 as the stable identity anchor, then attach disease evidence before program review.
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyltransferase, mapped to UniProt Q04631. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 377 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein farnesyltransferase as ChEMBL target CHEMBL2095197, mapped to UniProt Q04631. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Protein farnesyltransferase |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | Q04631 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha |
| UniProt Accession | Q04631 |
| Component Type | Protein |
| Sequence Length | 377 aa |
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Review this target as Protein farnesyltransferase, mapped to UniProt Q04631. ChEMBL maps the protein component as Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha. Sequence length is 377 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL310586 | 10.49 | IC50 | 0.032 | Preclinical |
| CHEMBL525369 | 10.27 | IC50 | 0.054 | Preclinical |
| CHEMBL516874 | 10.2 | IC50 | 0.063 | Preclinical |
| CHEMBL358363 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL344771 | 9.8 | IC50 | 0.16 | Preclinical |
| CHEMBL175628 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL367324 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL311561 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL144175 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL344100 | 9.7 | IC50 | 0.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 21 | 140 | 7.2 |
| assay format | 17 | 106 | 7.2 |
| cell-based format | 1 | 23 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 16 | 7.2 |