Compound Detail
CHEMBL310586
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Basic Information
| ChEMBL ID | CHEMBL310586 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BDXLTTUQHGMFEE-UHFFFAOYSA-N |
3
Targets
6
Activities
2
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
461.5
MW (Da)
4.47
ALogP
6
HBA
1
HBD
83.2
PSA (Ų)
0.42
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 10.49
EC50 2 meas. best 9.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2095197 | IC50 | 10.49 | 10.49 | 0.0 | 1 |
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 10.22 | 9.555 | 0.1 | 2 |
| Protein farnesyltransferase CHEMBL2094108 | EC50 | 9.24 | 9.205 | 0.6 | 2 |
| Geranylgeranyl transferase type I CHEMBL2095164 | IC50 | 6.09 | 6.09 | 810.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 8.0 | mL.min-1.kg-1 | Canis lupus familiaris |
| T1/2 | 0.88 | hr | Canis lupus familiaris |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 0.032 | nM | 10.49 | Inhibition of Farnesyltransferase in cells, evaluated in a radiotracer assay for... | 12036349 |
| Protein farnesyltransferase | IC50 | = | 0.06 | nM | 10.22 | Inhibition of Farnesyltransferase in PSN-1 cells at 10 pM | 12036349 |
| Protein farnesyltransferase | EC50 | = | 0.58 | nM | 9.24 | Inhibition of HDJ2 farnesylation in PSN-1 cells over 7 hr assay in the presence ... | 12036349 |
| Protein farnesyltransferase | EC50 | = | 0.67 | nM | 9.17 | Inhibition of HDJ2 farnesylation in PSN-1 cells over 7 hr assay | 12036349 |
| Protein farnesyltransferase | IC50 | = | 1.3 | nM | 8.89 | Inhibition of human farnesyltransferase in PSN-1 cells. | 12036349 |
| Geranylgeranyl transferase type I | IC50 | = | 810.0 | nM | 6.09 | Inhibitory activity against geranylgeranyl transferase | 12036349 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12036349 | 10.1021/jm010531d | Protein farnesyltransferase | 5 |
| 12036349 | 10.1021/jm010531d | Canis familiaris | 3 |
| 12036349 | 10.1021/jm010531d | Cytochrome P450 3A4 | 2 |
| 12036349 | 10.1021/jm010531d | Geranylgeranyl transferase type I | 1 |
| 12036349 | 10.1021/jm010531d | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine