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Assay Detail

CHEMBL680579

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Ligand dependent recruitment of SRC1(676-700) peptide to human Farnesoid X-activated receptor by fluorescence resonance energy transfer assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Bile acid receptor (CHEMBL2047)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM.
J Med Chem (2000) 43 : 2971 -2974
PubMed 10956205 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 5.47 5.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL240597 CHENODIOL 4.0 1 5.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL240597 CHENODIOL EC50 = 3400.0 nM 5.47