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Assay Detail

CHEMBL680624

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Binding
Binding affinity for factor VIIa/TF
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 7 — Homologous single protein target
Curated By Autocuration

Target

Coagulation factor VII/tissue factor (CHEMBL2095194)
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Optimization of a screening lead for factor VIIa/TF.
Young WB, Kolesnikov A, Rai R, Sprengeler PA, Leahy EM, Shrader WD, Sangalang J, Burgess-Henry J, Spencer J, Elrod K, Cregar L.
Bioorg Med Chem Lett (2001) 11 : 2253 -2256
PubMed 11527709 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.59 10.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL73737 1 10.11
CHEMBL76325 1 8.52
CHEMBL72231 1 8.52
CHEMBL307381 1 8.30
CHEMBL73162 1 7.92
CHEMBL73118 1 7.57
CHEMBL310933 1 7.48
CHEMBL73411 1 7.39
CHEMBL76130 1 6.50
CHEMBL421303 1 6.37
CHEMBL430990 1 6.32
CHEMBL74177 1 6.02

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL73737 Ki = 0.078 nM 10.11
CHEMBL76325 Ki = 3.0 nM 8.52
CHEMBL72231 Ki = 3.0 nM 8.52
CHEMBL307381 Ki = 5.0 nM 8.30
CHEMBL73162 Ki = 12.0 nM 7.92
CHEMBL73118 Ki = 27.0 nM 7.57
CHEMBL310933 Ki = 33.0 nM 7.48
CHEMBL73411 Ki = 41.0 nM 7.39
CHEMBL76130 Ki = 320.0 nM 6.50
CHEMBL421303 Ki = 430.0 nM 6.37
CHEMBL430990 Ki = 480.0 nM 6.32
CHEMBL74177 Ki = 950.0 nM 6.02