Assay Detail
Binding
CHEMBL680644
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Binding affinity against Gamma-aminobutyric acid A receptor in rat brain synaptosomes after 30 minutes
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Synaptosomes |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A study of 3-amino-N-hydroxypropanesulfonamide derivatives as potential GABAB agonists and their fragmentation to 3-aminopropanesulfinic acid
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.33 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL545424 | — | — | 1 | 6.64 |
| CHEMBL553273 | — | — | 1 | 6.55 |
| CHEMBL149082 | TRAMIPROSATE | 3.0 | 1 | 6.52 |
| CHEMBL32102 | HOMOHYPOTAURINE | — | 1 | 6.33 |
| CHEMBL541547 | — | — | 1 | 6.21 |
| CHEMBL542848 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL545424 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL553273 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL149082 | TRAMIPROSATE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL32102 | HOMOHYPOTAURINE | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL541547 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL542848 | — | IC50 | = | 2000.0 | nM | 5.70 |