Assay Detail
Binding
CHEMBL680687
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In vitro binding affinity to the Gamma-aminobutyric acid A receptor complex in absence of GABA in rat cerebellum tissue
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebellum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
gamma-Aminobutyrate-A receptor modulation by 3-aryl-1-(arylsulfonyl)- 1,4,5,6-tetrahydropyridazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.41 | 5.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76367 | — | — | 1 | 5.95 |
| CHEMBL78307 | — | — | 1 | 5.86 |
| CHEMBL82083 | — | — | 1 | 5.70 |
| CHEMBL207538 | BREXANOLONE | 4.0 | 1 | 5.58 |
| CHEMBL79029 | — | — | 1 | 5.58 |
| CHEMBL1256760 | — | — | 1 | 5.52 |
| CHEMBL76738 | — | — | 1 | 5.42 |
| CHEMBL79238 | — | — | 1 | 5.27 |
| CHEMBL79231 | — | — | 1 | 5.08 |
| CHEMBL78599 | — | — | 1 | 5.00 |
| CHEMBL309204 | — | — | 1 | 5.00 |
| CHEMBL311213 | — | — | 1 | 5.00 |
| CHEMBL80685 | — | — | 1 | - |
| CHEMBL80518 | — | — | 1 | - |
| CHEMBL312660 | — | — | 1 | - |
| CHEMBL312265 | — | — | 1 | - |
| CHEMBL311927 | — | — | 1 | - |
| CHEMBL78483 | — | — | 1 | - |
| CHEMBL78695 | — | — | 1 | - |
| CHEMBL78461 | — | — | 1 | - |
| CHEMBL79273 | — | — | 1 | - |
| CHEMBL78422 | — | — | 1 | - |
| CHEMBL79384 | — | — | 1 | - |
| CHEMBL82476 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76367 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL78307 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL82083 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL207538 | BREXANOLONE | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL79029 | — | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL1256760 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL76738 | — | IC50 | = | 3770.0 | nM | 5.42 |
| CHEMBL79238 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL79231 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL78599 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL309204 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL311213 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL80685 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL80518 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL312660 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL312265 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL311927 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL78483 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL78695 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL78461 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL79273 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL78422 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL79384 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL82476 | — | IC50 | > | 11000.0 | nM | - |