Assay Detail
Functional
CHEMBL680826
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Inhibition of [3H]FPP incorporation into Ha-ras protein by Farnesyltransferase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
3-Aryl-4-aryloyl-1-(1H-imidazol-5-yl)methylpyrrole, a novel class of farnesyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.15 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54044 | — | — | 1 | 9.30 |
| CHEMBL431828 | — | — | 1 | 8.85 |
| CHEMBL98692 | — | — | 1 | 8.34 |
| CHEMBL101889 | — | — | 1 | 7.80 |
| CHEMBL330655 | — | — | 1 | 7.50 |
| CHEMBL98806 | — | — | 1 | 7.19 |
| CHEMBL317408 | — | — | 1 | 7.06 |
| CHEMBL102187 | — | — | 1 | 6.94 |
| CHEMBL319100 | — | — | 1 | 6.82 |
| CHEMBL319294 | — | — | 1 | 6.33 |
| CHEMBL98498 | — | — | 1 | 5.87 |
| CHEMBL101551 | — | — | 1 | 5.64 |
| CHEMBL101897 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54044 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL431828 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL98692 | — | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL101889 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL330655 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL98806 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL317408 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL102187 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL319100 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL319294 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL98498 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL101551 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL101897 | — | IC50 | = | 5000.0 | nM | 5.30 |