Assay Detail
Binding
CHEMBL680869
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Inhibition of the (-40 mV) current elicited by 100 uM glutamate by simultaneous co-application in xenopus oocytes injected with GluR1 flop RNA.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.30 | 6.87 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL152879 | — | — | 1 | 6.87 |
| CHEMBL269192 | — | — | 1 | 6.85 |
| CHEMBL345521 | — | — | 1 | 6.77 |
| CHEMBL152736 | — | — | 1 | 6.77 |
| CHEMBL152425 | — | — | 1 | 6.68 |
| CHEMBL153995 | — | — | 1 | 6.62 |
| CHEMBL352030 | — | — | 1 | 6.60 |
| CHEMBL350228 | — | — | 1 | 6.60 |
| CHEMBL154012 | — | — | 1 | 6.59 |
| CHEMBL355977 | — | — | 1 | 6.55 |
| CHEMBL153017 | — | — | 1 | 6.54 |
| CHEMBL422161 | — | — | 1 | 6.52 |
| CHEMBL153996 | — | — | 1 | 6.48 |
| CHEMBL152410 | — | — | 1 | 6.00 |
| CHEMBL422515 | — | — | 1 | 5.52 |
| CHEMBL434273 | — | — | 1 | 5.21 |
| CHEMBL147182 | — | — | 1 | 5.10 |
| CHEMBL154184 | — | — | 1 | 5.09 |
| CHEMBL55975 | — | — | 1 | - |
| CHEMBL152153 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL152879 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL269192 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL345521 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL152736 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL152425 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL153995 | — | Ki | = | 240.0 | nM | 6.62 |
| CHEMBL352030 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL350228 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL154012 | — | Ki | = | 254.0 | nM | 6.59 |
| CHEMBL355977 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL153017 | — | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL422161 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL153996 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL152410 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL422515 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL434273 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL147182 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL154184 | — | Ki | = | 8100.0 | nM | 5.09 |
| CHEMBL55975 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL152153 | — | Ki | > | 10000.0 | nM | - |