Compound Detail
CHEMBL154184
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL154184 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTDSKKPKSNZTHK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
436.6
MW (Da)
2.41
ALogP
6
HBA
6
HBD
119.6
PSA (Ų)
0.15
QED
1
Ro5 Violations
19
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 1 CHEMBL2009 | Ki | 6.46 | 5.775 | 350.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 6.05 | 6.05 | 900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 1 | Ki | = | 350.0 | nM | 6.46 | Inhibition of the (-80 mV) current elicited by 100 uM glutamate by simultaneous ... | 12477358 |
| Unchecked | Ki | = | 900.0 | nM | 6.05 | Inhibition of the current elicited by 100 uM glutamate by simultaneous co-applic... | 12477358 |
| Glutamate receptor 1 | Ki | = | 8100.0 | nM | 5.09 | Inhibition of the (-40 mV) current elicited by 100 uM glutamate by simultaneous ... | 12477358 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12477358 | 10.1021/jm020314s | Unchecked | 3 |
| 12477358 | 10.1021/jm020314s | Glutamate receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine