Assay Detail
Functional
CHEMBL680877
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the current elicited by 100 uM glutamate by simultaneous co-application of the antagonist in xenopus oocytes injected with a 1:1 mixture of GluR1 flop and GluR2 flop RNA as well as GluR5(Q).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.46 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL55975 | — | — | 1 | 7.82 |
| CHEMBL152879 | — | — | 1 | 7.22 |
| CHEMBL147182 | — | — | 1 | 6.60 |
| CHEMBL422515 | — | — | 1 | 6.54 |
| CHEMBL152153 | — | — | 1 | 6.10 |
| CHEMBL154184 | — | — | 1 | 6.05 |
| CHEMBL434273 | — | — | 1 | 5.68 |
| CHEMBL153017 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL55975 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL152879 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL147182 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL422515 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL152153 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL154184 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL434273 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL153017 | — | Ki | = | 2200.0 | nM | 5.66 |