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Assay Detail

CHEMBL680876

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards GluR4 receptor from rat brain
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Glutamate receptor 4 (CHEMBL3505)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties.
Campiani G, Morelli E, Nacci V, Fattorusso C, Ramunno A, Novellino E, Greenwood J, Liljefors T, Griffiths R, Sinclair C, Reavy H, Kristensen AS, Pickering DS, Schousboe A, Cagnotto A, Fumagalli E, Mennini T.
J Med Chem (2001) 44 : 4501 -4504
PubMed 11741469 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.75 5.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL337577 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL337577 Ki = 1756.0 nM 5.75