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Assay Detail

CHEMBL680918

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Binding
Inhibition of Glutamate carboxypeptidase II
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Glutamate carboxypeptidase 2 (CHEMBL1892)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of hydroxamate-Based inhibitors of glutamate carboxypeptidase II.
Stoermer D, Liu Q, Hall MR, Flanary JM, Thomas AG, Rojas C, Slusher BS, Tsukamoto T.
Bioorg Med Chem Lett (2003) 13 : 2097 -2100
PubMed 12798312 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 6.30 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL47009 1 9.52
CHEMBL64901 1 7.09
CHEMBL303352 1 7.05
CHEMBL65043 1 6.66
CHEMBL433298 1 6.03
CHEMBL63454 1 5.92
CHEMBL432726 1 5.40
CHEMBL65860 1 4.70
CHEMBL51979 1 4.37
CHEMBL63893 GLUTAMINE HYDROXAMATE 1 -
CHEMBL65072 1 -
CHEMBL294281 1 -
CHEMBL63902 1 -
CHEMBL413963 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL47009 IC50 = 0.3 nM 9.52
CHEMBL64901 IC50 = 82.0 nM 7.09
CHEMBL303352 IC50 = 90.0 nM 7.05
CHEMBL65043 IC50 = 220.0 nM 6.66
CHEMBL433298 IC50 = 940.0 nM 6.03
CHEMBL63454 IC50 = 1200.0 nM 5.92
CHEMBL432726 IC50 = 4000.0 nM 5.40
CHEMBL65860 IC50 = 20000.0 nM 4.70
CHEMBL51979 IC50 = 43000.0 nM 4.37
CHEMBL63893 GLUTAMINE HYDROXAMATE IC50 > 100000.0 nM -
CHEMBL65072 IC50 > 100000.0 nM -
CHEMBL294281 IC50 > 100000.0 nM -
CHEMBL63902 IC50 > 100000.0 nM -
CHEMBL413963 IC50 > 100000.0 nM -