Assay Detail

CHEMBL681039

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Binding

Inhibitory activity against beta-Lactamase enzyme derived from Escherichia coli WC3310 TEM-2

ChEMBL ↗

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Target

Beta-lactamase TEM (CHEMBL2065) ↗

Open DB target context

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Primary target Beta-lactamase TEM

CHEMBL2065

Anchored from Assay target.

Protein identity Beta-lactamase TEM

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Escherichia coli
Confidence	9 — Direct single protein target
Curated By	Intermediate

Target

Beta-lactamase TEM (CHEMBL2065) ↗

Type	SINGLE PROTEIN
Organism	Escherichia coli

Publication

The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins

Buynak JD, Geng B, Bachmann B, Ling Hua
Bioorg Med Chem Lett (1995) 5 : 1513 -1518
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.60	7.60

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL404	TAZOBACTAM	4.0	1	7.60

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL404	TAZOBACTAM	IC50	=	25.0	nM	7.60