Assay Detail
Binding
CHEMBL681135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor from rat brain synaptic membranes.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.05 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307931 | — | — | 1 | 7.48 |
| CHEMBL292757 | — | — | 1 | 4.82 |
| CHEMBL309689 | — | — | 1 | 4.82 |
| CHEMBL150830 | — | — | 1 | 4.14 |
| CHEMBL309688 | — | — | 1 | 4.00 |
| CHEMBL74364 | — | — | 1 | - |
| CHEMBL305673 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307931 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL292757 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL309689 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL150830 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL309688 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL74364 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL305673 | — | IC50 | > | 100000.0 | nM | - |