Assay Detail
Binding
CHEMBL681136
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]GABA binding to Gamma-aminobutyric acid receptor of rat brain synaptic membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gamma-aminobutyric acid receptor subunit gamma-1 (CHEMBL296) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.42 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42464 | — | — | 1 | 8.40 |
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | 8.22 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.48 |
| CHEMBL40804 | — | — | 1 | 6.60 |
| CHEMBL296263 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42464 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL273481 | MUSCIMOL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL40804 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL296263 | — | IC50 | = | 400.0 | nM | 6.40 |