Assay Detail
Binding
CHEMBL681137
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]P4S binding to Gamma-aminobutyric acid receptor of rat brain synaptic membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | 8.22 |
| CHEMBL42464 | — | — | 1 | 8.10 |
| CHEMBL40363 | — | — | 1 | 7.75 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 7.60 |
| CHEMBL40804 | — | — | 1 | 6.27 |
| CHEMBL296263 | — | — | 1 | 6.05 |
| CHEMBL290216 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL42464 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL40363 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL40804 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL296263 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL290216 | — | IC50 | = | 1900.0 | nM | 5.72 |