Assay Detail
Binding
CHEMBL681241
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition against Gamma-aminobutyric acid A (GABA-A) receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.56 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | 8.22 |
| CHEMBL312443 | GABOXADOL | 3.0 | 1 | 6.89 |
| CHEMBL81327 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273481 | MUSCIMOL | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL312443 | GABOXADOL | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL81327 | — | IC50 | > | 100000.0 | nM | - |