Assay Detail
Binding
CHEMBL681272
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]muscimol binding to GABA A receptor 4-biphenylacetic acid at 10 e-4 M
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL1907607) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Quinolone antimicrobial agents substituted with morpholines at the 7-position. Syntheses and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.49 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9 | NORFLOXACIN | 4.0 | 1 | 7.70 |
| CHEMBL15549 | — | — | 1 | 6.92 |
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 6.39 |
| CHEMBL4 | OFLOXACIN | 4.0 | 1 | 4.96 |
| CHEMBL29929 | — | — | 1 | - |
| CHEMBL28858 | — | — | 1 | - |
| CHEMBL27345 | — | — | 1 | - |
| CHEMBL29572 | — | — | 1 | - |
| CHEMBL26523 | — | — | 1 | - |
| CHEMBL282127 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9 | NORFLOXACIN | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL15549 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL8 | CIPROFLOXACIN | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4 | OFLOXACIN | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL29929 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL28858 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL27345 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL29572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL26523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL282127 | — | IC50 | > | 100000.0 | nM | - |