Assay Detail
Functional
CHEMBL681450
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its ability to inhibit uptake of [3H]- GABA by cloned human GAT-1 transporter
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Sodium- and chloride-dependent GABA transporter 1 (CHEMBL1903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
On the bioactive conformation of the gaba uptake inhibitor SK&F 89976-A
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.89 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38686 | — | — | 1 | 6.89 |
| CHEMBL2093978 | — | — | 1 | - |
| CHEMBL2094022 | — | — | 1 | - |
| CHEMBL2093977 | — | — | 1 | - |
| CHEMBL2094024 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38686 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2093978 | — | IC50 | = | 632000.0 | nM | - |
| CHEMBL2094022 | — | IC50 | = | 270000.0 | nM | - |
| CHEMBL2093977 | — | IC50 | = | 809000.0 | nM | - |
| CHEMBL2094024 | — | IC50 | = | 270000.0 | nM | - |