Assay Detail
Binding
CHEMBL681468
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Inhibition of [3H]farnesyl pyrophosphate binding to human farnesyltransferase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
A novel metal-chelating inhibitor of protein farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.41 | 5.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39572 | — | — | 1 | 5.72 |
| CHEMBL289404 | — | — | 1 | 5.60 |
| CHEMBL285848 | MANUMYCIN A | — | 1 | 4.92 |
| CHEMBL39879 | DIPYRIDYL | — | 1 | - |
| CHEMBL816 | ETHYLENEDIAMINE | 3.0 | 1 | - |
| CHEMBL36582 | — | — | 1 | - |
| CHEMBL415879 | PHENANTHROLINE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39572 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL289404 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL285848 | MANUMYCIN A | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL39879 | DIPYRIDYL | IC50 | = | 100000000.0 | nM | - |
| CHEMBL816 | ETHYLENEDIAMINE | IC50 | = | 15500000.0 | nM | - |
| CHEMBL36582 | — | IC50 | = | 620000.0 | nM | - |
| CHEMBL415879 | PHENANTHROLINE | IC50 | = | 4000000.0 | nM | - |