Assay Detail
Binding
CHEMBL681607
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In vitro inhibition of Farnesyltransferase (FT) by using FT [3H]-SPA kit.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Successful virtual screening of a chemical database for farnesyltransferase inhibitor leads.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.18 | 4.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298301 | — | — | 1 | 4.60 |
| CHEMBL133894 | — | — | 1 | 4.10 |
| CHEMBL131204 | — | — | 1 | 4.02 |
| CHEMBL335510 | — | — | 1 | 4.00 |
| CHEMBL132497 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298301 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL133894 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL131204 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL335510 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL132497 | — | IC50 | = | 110000.0 | nM | - |