Assay Detail
Binding
CHEMBL681644
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Inhibition of farnesyl transferase (FTase) of rat brain
14
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Protein farnesyltransferase (CHEMBL2095197) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Constrained analogs of KCVFM with improved inhibitory properties against farnesyl transferase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.63 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL299956 | — | — | 1 | 8.30 |
| CHEMBL2115457 | — | — | 1 | 7.70 |
| CHEMBL48182 | — | — | 1 | 7.40 |
| CHEMBL50624 | — | — | 1 | 6.00 |
| CHEMBL51436 | — | — | 1 | 6.00 |
| CHEMBL433279 | — | — | 1 | 6.00 |
| CHEMBL297242 | — | — | 1 | 6.00 |
| CHEMBL2115458 | — | — | 1 | 5.70 |
| CHEMBL2115025 | — | — | 2 | 4.82 |
| CHEMBL289302 | — | — | 1 | 4.60 |
| CHEMBL3350314 | — | — | 2 | 4.30 |
| CHEMBL3350692 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL299956 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL2115457 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL48182 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL50624 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL51436 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL433279 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL297242 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2115458 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2115025 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL289302 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL3350314 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3350314 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3350692 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL2115025 | — | IC50 | = | 100000.0 | nM | 4.00 |