Assay Detail
Binding
CHEMBL681671
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Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Geranylgeranyl pyrophosphate synthase (CHEMBL4769) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.62 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL71360 | — | — | 1 | 6.85 |
| CHEMBL419627 | — | — | 1 | 6.51 |
| CHEMBL67986 | — | — | 1 | 6.43 |
| CHEMBL54004 | — | — | 1 | 6.14 |
| CHEMBL71017 | — | — | 1 | 6.13 |
| CHEMBL416301 | — | — | 1 | 6.04 |
| CHEMBL298852 | — | — | 1 | 5.85 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 5.66 |
| CHEMBL298547 | — | — | 1 | 5.37 |
| CHEMBL55264 | — | — | 1 | 4.96 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | — | 1 | 4.72 |
| CHEMBL299988 | — | — | 1 | 4.28 |
| CHEMBL997 | IBANDRONIC ACID | 4.0 | 1 | 4.08 |
| CHEMBL305530 | — | — | 1 | - |
| CHEMBL299491 | — | — | 1 | - |
| CHEMBL55557 | — | — | 1 | - |
| CHEMBL68666 | — | — | 1 | - |
| CHEMBL56556 | — | — | 1 | - |
| CHEMBL55358 | — | — | 1 | - |
| CHEMBL417932 | — | — | 1 | - |
| CHEMBL52761 | — | — | 1 | - |
| CHEMBL55214 | NERIDRONIC ACID | 3.0 | 1 | - |
| CHEMBL301247 | — | — | 1 | - |
| CHEMBL870 | ALENDRONIC ACID | 4.0 | 1 | - |
| CHEMBL834 | PAMIDRONIC ACID | 4.0 | 1 | - |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | - |
| CHEMBL293522 | — | — | 1 | - |
| CHEMBL55140 | — | — | 1 | - |
| CHEMBL55359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL71360 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL419627 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL67986 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL54004 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL71017 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL416301 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL298852 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL52251 | (OCTYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL298547 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL55264 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL56254 | (HEXYLAMINO)METHYLENEDIPHOSPHONIC ACID | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL299988 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL997 | IBANDRONIC ACID | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL305530 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL299491 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL55557 | — | IC50 | = | 260000.0 | nM | - |
| CHEMBL68666 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL56556 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL55358 | — | IC50 | = | 330000.0 | nM | - |
| CHEMBL417932 | — | IC50 | = | 180000.0 | nM | - |
| CHEMBL52761 | — | IC50 | = | 620000.0 | nM | - |
| CHEMBL55214 | NERIDRONIC ACID | IC50 | = | 690000.0 | nM | - |
| CHEMBL301247 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL870 | ALENDRONIC ACID | IC50 | = | 440000.0 | nM | - |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 180000.0 | nM | - |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 350000.0 | nM | - |
| CHEMBL293522 | — | IC50 | = | 410000.0 | nM | - |
| CHEMBL55140 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL55359 | — | IC50 | = | 550000.0 | nM | - |