Assay Detail
Binding
CHEMBL681672
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL protein
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of hydroxyproline-derived isoprenyltransferase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.56 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL62387 | — | — | 1 | 9.00 |
| CHEMBL305536 | — | — | 1 | 7.96 |
| CHEMBL2092855 | — | — | 1 | 7.28 |
| CHEMBL63366 | — | — | 1 | 7.05 |
| CHEMBL65257 | — | — | 1 | 7.00 |
| CHEMBL303414 | — | — | 1 | 6.96 |
| CHEMBL67663 | — | — | 1 | 6.82 |
| CHEMBL305584 | — | — | 1 | 6.77 |
| CHEMBL307974 | — | — | 1 | 6.75 |
| CHEMBL3349357 | — | — | 1 | 6.70 |
| CHEMBL67174 | — | — | 1 | 6.68 |
| CHEMBL432538 | — | — | 1 | 6.60 |
| CHEMBL306018 | — | — | 1 | 6.24 |
| CHEMBL303509 | — | — | 1 | 5.48 |
| CHEMBL63663 | — | — | 1 | 5.10 |
| CHEMBL2092731 | — | — | 1 | 4.96 |
| CHEMBL3349310 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL62387 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL305536 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2092855 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL63366 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL65257 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL303414 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL67663 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL305584 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL307974 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3349357 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL67174 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL432538 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL306018 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL303509 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL63663 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2092731 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3349310 | — | IC50 | = | 67000.0 | nM | 4.17 |