Assay Detail
Binding
CHEMBL681675
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Inhibition of [3H]GGPP incorporation into recombinant human Ha-RasCVLL by Geranylgeranyl transferase from bovine brain
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Design and in vivo analysis of potent non-thiol inhibitors of farnesyl protein transferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.50 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252953 | — | — | 1 | 7.17 |
| CHEMBL324081 | — | — | 1 | 7.04 |
| CHEMBL114739 | — | — | 1 | 5.66 |
| CHEMBL326210 | — | — | 1 | 5.30 |
| CHEMBL322355 | — | — | 1 | 5.09 |
| CHEMBL115502 | — | — | 1 | 5.00 |
| CHEMBL327106 | — | — | 1 | 5.00 |
| CHEMBL321252 | — | — | 1 | 5.00 |
| CHEMBL325840 | — | — | 1 | 5.00 |
| CHEMBL114990 | — | — | 1 | 4.76 |
| CHEMBL114146 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252953 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL324081 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL114739 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL326210 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL322355 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL115502 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL327106 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL321252 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL325840 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL114990 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL114146 | — | IC50 | 90.0 | nM | - |