Assay Detail
Functional
CHEMBL681737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of antagonist activity towards glucocorticoid receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.66 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.10 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.57 |
| CHEMBL62227 | — | — | 1 | 6.71 |
| CHEMBL64294 | — | — | 1 | 6.16 |
| CHEMBL293409 | — | — | 1 | 5.73 |
| CHEMBL63870 | — | — | 1 | 5.71 |
| CHEMBL62761 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL62227 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL64294 | — | IC50 | = | 689.0 | nM | 6.16 |
| CHEMBL293409 | — | IC50 | = | 1872.0 | nM | 5.73 |
| CHEMBL63870 | — | IC50 | = | 1929.0 | nM | 5.71 |
| CHEMBL62761 | — | IC50 | = | 2170.0 | nM | 5.66 |