Assay Detail
Binding
CHEMBL681746
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Binding affinity for human glucocorticoid receptor expressed in CV-1 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation, resolution, and biological evaluation of 5-aryl-1, 2-dihydro-5H-chromeno[3,4-f]quinolines: potent, orally active, nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.40 | 8.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104183 | — | — | 1 | 8.20 |
| CHEMBL94753 | — | — | 1 | 7.85 |
| CHEMBL416411 | — | — | 1 | 6.88 |
| CHEMBL94749 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104183 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL94753 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL416411 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL94749 | — | Ki | = | 210.0 | nM | 6.68 |